Serum alpha-fetoprotein levels in extrahepatic biliary atresia, idiopathic neonatal hepatitis and alpha-1-antitrypsin deficiency (PiZ).
Acta Paediatr Scand
; 65(5): 623-9, 1976 Sep.
Article
em En
| MEDLINE
| ID: mdl-60872
ABSTRACT
Serum alpha-fetoprotein levels were measured using a sensitive radioimmunoassay in 77 infants presenting with persistent conjugated hyperbilirubinaemia. A breed range of alpha-fetoprotein concentrations occurred in both the 23 infants with extrahepatic biliary atresia and the 35 with idiopathic neonatal hepatitis but the 13 with alpha-1-antitrypsin deficiency had uniformly low levels. High alpha-fetoprotein concentrations (above 10 000 mug/1) favoured the diagnosis of neonatal hepatitis especially in the first ten weeks of life, but the overlap between neonatal hepatitis and extrahepatic biliary atresia was large and alpha-fetoprotein determination cannot be recommended as a reliable method for distinguishing the two conditions. Serial alpha-fetoprotein values showed no consistent relationship with standard liver function tests and gave no guide to prognosis. There was an association between alpha-fetoprotein production and needle biopsy evidence of hepatic giant cell transformation. The uniformly low alpha-fetoprotein levels in alpha-1-antitrypsin deficient infants with neonatal hepatitis is a new observation and possible mechanisms for disordered glycoprotein release are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Biliares
/
Alfa-Fetoproteínas
/
Deficiência de alfa 1-Antitripsina
/
Proteínas Fetais
/
Hepatite
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Infant
/
Newborn
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article