Glucose metabolism and acetylcholine synthesis in relation to neuronal activity in Alzheimer's disease.
Lancet
; 1(8164): 333-6, 1980 Feb 16.
Article
em En
| MEDLINE
| ID: mdl-6101790
ABSTRACT
The metabolism of (U--14C) glucose and its incorporation into acetylcholine were determined in vitro in fresh cortical biopsy samples from patients with Alzheimer's disease and controls. Synthesis of 14C acetylcholine was significantly reduced (60% and 67% reduction under stimulated and resting conditions, respectively) without significant changes in the overall metabolism of glucose (as measured by 14CO2 production). Acetylcholine synthesis was directly related to the activity of choline acetyltransferase. The changes in cholinergic markers reflected the severity of psychological defects. Acetylcholine synthesis was not reduced in biopsy samples from patients suffering from presenile dementia with no histological evidence of Alzheimer's disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lobo Temporal
/
Acetilcolina
/
Córtex Cerebral
/
Receptores Colinérgicos
/
Demência
/
Doença de Alzheimer
/
Glucose
Limite:
Aged
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article