Neurotransmitter control of hypothalamic-pituitary-thyroid function in rats.
Eur J Pharmacol
; 70(3): 263-71, 1981 Mar 26.
Article
em En
| MEDLINE
| ID: mdl-6112152
ABSTRACT
The possible roles of monoamine neurotransmitters in the regulation of the hypothalamic-pituitary-thyroid axis were examined in the rat. Rats were treated acutely and repeatedly with drugs which are presumed to alter neurotransmitter functional activity. These drugs include neurotransmitter precursors (tryptophan and L-DOPA), synthesis inhibitors (p-chlorophenylalanine and alpha-methyltyrosine), uptake inhibitors (desipramine and zimelidine) and lithium carbonate. The hormone levels measured were hypothalamic TRH and SLI content and serum TSH, T4 and T3. We conclude that augmented serotonergic or dopaminergic activity may inhibit TRH release, but that release from these inhibitions is not sufficient to stimulate TRH release. The release of TRH seems to be mediated by norepinephrine. Lithium treatment results in increased hypothalamic TRH.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
/
Neurotransmissores
/
Sistema Hipotálamo-Hipofisário
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article