[Thyroid pathology and lymphoproliferative diseases]. / Pathologie thyroïdienne et maladies lymphoprolifératives.
Ann Endocrinol (Paris)
; 44(2): 115-9, 1983.
Article
em Fr
| MEDLINE
| ID: mdl-6137184
ABSTRACT
Four cases are reported, of an association between a thyroidal illness (1 hypothyroidism, 3 hyperthyroidism) on one hand, and a lymphocytic proliferation and/or monoclonal gammapathy on the other. The following findings:
HLA B8 or DrW3 in 3, antithyroid antibodies at a very high level in 2, and thyroid stimulating immunoglobulin in 2 support the conclusion of thyroidal diseases of auto-immune nature. Simultaneous appearance of both thyroidal and hematologic illness favors the hypothesis of a non coincidental association. A direct thyroidal activity of the monoclonal paraprotein has been found only once among the 4 published and our 2 cases in which it has been studied. A more likely link would be a common physiopathology a functional deficiency of T suppressor lymphocytes allowing the proliferation of a cellular clone producing an abnormal immunoglobulin, would also allow the development of a thyroidal illness when favored by a genetic predisposition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças da Glândula Tireoide
/
Transtornos Linfoproliferativos
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Fr
Ano de publicação:
1983
Tipo de documento:
Article