Synthesis of human cytomegalovirus-specified RNA and protein in interferon-treated cells at early times after infection.
J Gen Virol
; 60(Pt 2): 261-70, 1982 Jun.
Article
em En
| MEDLINE
| ID: mdl-6180127
ABSTRACT
In human fibroblast cells treated with interferon, cytomegalovirus-specified immediate early RNA was found associated with the polyribosomes at concentrations and size classes similar to the virus RNA found in non-treated cells, Interferon treatment inhibited the translation of the immediate early virus mRNA; the relative rate of virus-specified immediate early protein and antigen synthesis decreased with increasing concentrations of interferon. In addition, the relative amount of virus-specified RNA associated with the polyribosomes at early times after infection was significantly reduced by treatment of the cells with interferon. Inhibition of infectious virus production in interferon-treated cells was primarily due to inhibition of immediate early virus protein synthesis and secondarily to suppression of early virus RNA synthesis. The role of the virus-specified immediate early proteins in regulating subsequent virus gene expression is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
/
RNA Viral
/
Interferons
/
Citomegalovirus
Limite:
Humans
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article