Suppression of IgE antibody production in SJL mice. V. Effect of irradiation and adult thymectomy on the suppression of IgE antibody production in SJL mice.
Cell Immunol
; 79(2): 407-9, 1983 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-6223711
ABSTRACT
Anti-DNP IgE antibody production was low and transient in SJL mice which were immunized with 1 microgram DNP-Nb and 1 mg A1(OH)3. The immunized SJL mice were irradiated (60-540 R) 1 day after challenge. A dose higher than 180 R induced enhancement of anti-DNP IgE antibody production as compared to nonirradiated control mice, suggesting the existence of irradiation-sensitive suppressor cells. Anti-DNP IgE antibody production was suppressed when immunized and irradiated SJL mice were injected with spleen cells from adult-thymectomized SJL mice. The donors of the spleen cells were thymectomized 2 or 4 months previously, and this suggests that the suppressor cells from unprimed mice are long-living T cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timectomia
/
Imunoglobulina E
/
Linfócitos T Reguladores
Limite:
Animals
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article