Peripheral serotonergic receptor sensitivity in depressive illness.
J Affect Disord
; 7(1): 59-65, 1984 Aug.
Article
em En
| MEDLINE
| ID: mdl-6236244
ABSTRACT
Platelet aggregation induced by 5-HT was used as a measure of the functional responsiveness of peripheral 5-HT receptors in controls and drug-free depressed patients. No significantly different aggregatory response (5-HT/ADP ratio) was noted between the controls and drug-free depressed patients. If the receptor mediating this response is a 5-HT2 receptor, there is no overwhelming evidence to suggest that the functional activity of this system is abnormal during a depressive illness. The results are discussed with reference to reported abnormalities of 5-HT2 receptors during a depressive illness and to their change during antidepressant treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Serotonina
/
Transtorno Depressivo
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article