Anti-tremor action of C10Dichol, a peripheral acetylcholine synthesis inhibitor.
Br J Pharmacol
; 71(1): 349-53, 1980.
Article
em En
| MEDLINE
| ID: mdl-6258692
ABSTRACT
1 Anti-tremor action of decamethylene bis-(hydroxyethyl)-dimethylammonium bromide (C10Dichol), a peripheral acetylcholine synthesis inhibitor, was investigated. 2 C10Dichol inhibited tremor induced by oxotremorine, nicotine and physostigmine and afforded partial protection from physostigmine-induced mortality in mice. 3 In non-paralysing doses, C10Dichol antagonized the neuromuscular effects of oxotremorine, nicotine and physostigmine. 4 Prior administration of C10Dichol failed to prevent tremor and neuromuscular paralysis induced by harmine and arecoline. 5 In the absence of any antimuscarinic property of C10Dichol, its neuromuscular effects appeared to be casually related to its anti-tremor action. 6 This study reveals a possibility for the development of peripherally acting anti-Parkinson drugs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tremor
/
Acetilcolina
/
Compostos de Amônio Quaternário
Limite:
Animals
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article