Lipid analysis in nerve biopsy specimens of hypertrophic neuropathy.
Arch Neurol
; 38(7): 436-8, 1981 Jul.
Article
em En
| MEDLINE
| ID: mdl-6264902
ABSTRACT
We performed a lipid analysis on nerve biopsy specimens in two cases of degenerative hypertrophic neuropathy. Quantitative analysis of the major lipid classes, ie, cholesterol, cerebrosides, sulfatides, ethanolamine phospholipids, phosphatidyl-choline, phosphatidyl-serine, phosphatidyl-inositol, sphingomyelin, and gangliosides, were performed. The two cases exhibited extreme decreases in levels of lipids that could be related to the very low myelin content of these nerves. Cholesterol and phospholipid levels were especially reduced. Cerebrosides and sulfatides were not modified in the same proportion, as could have been predicted from the degree of demyelination. This relative glycolipid increase could be due to the very high Schwann cell proliferation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nervo Fibular
/
Doenças do Sistema Nervoso Periférico
/
Metabolismo dos Lipídeos
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article