Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
J Med Chem
; 24(6): 759-60, 1981 Jun.
Article
em En
| MEDLINE
| ID: mdl-6265638
ABSTRACT
(Z)-5-(2-Bromovinyl)uracil was obtained by photoisomerization of the E. isomer. Similarly, (E)-5-(2-bromovinyl)-2'-deoxyuridine gave the required Z isomer. (Z)-5-(2-Bromovinyl)-2'-deoxyuridine is much less active against herpes simplex virus type 1 (HSV-1) and somewhat less active against herpes simplex virus type 2 than is the E isomer. Both isomers show similar activity against vaccinia virus. Therefore, the highly potent and selective activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against HSV-1 is due to its E configuration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Bromodesoxiuridina
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article