Poly(ADP-ribose) synthesis in human cervical cancer cell-diagnostic cytological usefulness.
Cancer Lett
; 14(3): 227-36, 1981 Dec.
Article
em En
| MEDLINE
| ID: mdl-6277470
ABSTRACT
Poly(ADP-ribose) synthetase activity in human cervical cancer cell nuclei was found to be approximately twice that of normal cervical cell nuclei. Using antipoly(ADP-ribose) antibody, frozen section of normal tissue were stained by indirect-immunofluorescence and it was demonstrated that the fluorescence of nuclei in squamous cells decreased during maturation. Correspondingly, superficial cells appearing in smear specimens had less nuclear fluorescence compared with parabasal cells in the same smear. However, cancer cells in cervical smears had marked nuclear fluorescence using immunostaining and were easily distinguished from normal cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poli Adenosina Difosfato Ribose
/
Neoplasias do Colo do Útero
/
Poli(ADP-Ribose) Polimerases
/
NAD/ Nucleosidase
/
Ensaios Enzimáticos Clínicos
/
Açúcares de Nucleosídeo Difosfato
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article