[3H]CL 218,872, a novel triazolopyridazine which labels the benzodiazepine receptors in rat brain.
Eur J Pharmacol
; 77(4): 351-4, 1982 Feb 05.
Article
em En
| MEDLINE
| ID: mdl-6277678
ABSTRACT
We examined the specific binding of [3H]CL 218,872, a novel triazolopyridazine to benzodiazepine receptors in the rat cerebral cortex. Two binding sites with KD values of about 10-30 nM and 200-600 nM were demonstrated. A number of benzodiazepine anxiolytics inhibited [3H]CL 218,872 binding in a manner which correlates with the potency of these drugs for inhibiting [3H]benzodiazepine binding. Our initial studies show that [3H]CL 218,872 can label the benzodiazepine receptors and may prove to be a useful probe for studying benzodiazepine heterogeneity and regulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridazinas
/
Receptores de Droga
/
Córtex Cerebral
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article