Bombesin production by human small cell carcinoma of the lung.
Regul Pept
; 4(2): 59-66, 1982 Jul.
Article
em En
| MEDLINE
| ID: mdl-6289385
ABSTRACT
A series of continuous cell lines of human small cell carcinoma of the lung (SCCL) have been evaluated for the production of bombesin (BN). In early established cultures BN was detected in the medium of 9 out of 11 cell lines and in 6 out of 7 cell homogenates examined. Levels in the medium were frequently higher in cultures of later passages compared to earlier passages of the same line and low levels developed in the two previously negative cell lines. Plasma concentrations were greater than 80 pmol/l in 2 out of 27 (7%) randomly selected patients with SCCL. A culture (DMS 406) established from the tumor of a patient with the highest plasma level (1240 pmol/l) was the highest producer in vitro. The results indicate that BN, which has been demonstrated immunocytochemically to be present in normal bronchial mucosal cells, is frequently produced by SCCL in vitro but elevated plasma levels are infrequently found in patients with this neoplasm.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese Peptídica
/
Bombesina
/
Carcinoma de Células Pequenas
/
Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article