Clinical toxicity of combined modality treatment with nitrosourea derivatives for central nervous system tumors.
Neurosurgery
; 11(3): 408-11, 1982 Sep.
Article
em En
| MEDLINE
| ID: mdl-6290930
ABSTRACT
Two nitrosourea compounds--1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)--have been used in the treatment of primary and metastatic brain tumors after operation and/or radiotherapy. Hematological and nonhematological toxicity were recorded in 272 patients treated between May 1973 and June 1978. BCNU was given to 135 patients (80 mg/m2 i.v. daily for 3 days) and CCNU was given to 137 patients (130 mg/m2 orally, single dose) every 8 weeks until progression of the primary disease process or for a total of 12 cycles. Radiation therapy (5500 +/- 500 rads in 6 to 7 weeks) was carried out after the first course of chemotherapy. BCNU and CCNU induced the same hematological and clinical toxicity. The bone marrow toxicity seemed to be dose-related, delayed, and cumulative. One case of acute nonlymphoblastic leukemia arising 2 months after the end of CCNU therapy is reported.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças da Medula Óssea
/
Carmustina
/
Leucemia
/
Gastroenteropatias
/
Doenças Hematológicas
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Lomustina
/
Compostos de Nitrosoureia
Limite:
Humans
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article