Synthesis and biological properties of 2'-deoxy-5-vinyluridine and 2'deoxy-5-vinylcytidine.
Nucleic Acids Res
; 10(17): 5285-95, 1982 Sep 11.
Article
em En
| MEDLINE
| ID: mdl-6292837
ABSTRACT
Rapid and efficient syntheses for the preparation of 2'-deoxy-5-vinyluridine and 2'-deoxy-5-vinylcytidine are described starting from nucleoside precursors. Contrary to some previous reports, 2-deoxy-5-vinyluridine has be found to be quite stable under normal laboratory conditions but when tested in animals shows neither toxicity nor anti-leukemic (L1210 cells) or anti-parasitic (Plasmodium berghei) activity. 2'-Deoxy-5-vinylcytidine appears to polymerise readily. It is much less toxic to cell cultures than 2'-deoxy-5'vinyluridine but is almost as active against herpes virus replication (ID500.2 microgram/ml) for both type 1 and type 2 herpes virus (selectivity index225).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Desoxicitidina
/
Desoxiuridina
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article