Dolichol induces membrane leakage of liposomes composed of phosphatidylethanolamine and phosphatidylcholine.
FEBS Lett
; 169(2): 279-82, 1984 Apr 24.
Article
em En
| MEDLINE
| ID: mdl-6325244
ABSTRACT
Dolichol promotes the leakage of membranes in liposomes composed of phosphatidylethanolamine and phosphatidylcholine but not liposomes composed only of phosphatidylcholine. The membrane leakage was assayed by measuring the entrapment of TEMPOcholine, a cationic spin probe, in liposomes using ESR methods. The percent of membrane leakage induced by dolichol was found to be linearly proportional to the concentrations of dolichol. It is proposed that dolichol enhances the formation of non-bilayer configurations in liposomes containing phosphatidylethanolamine, thereby membrane leakage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilcolinas
/
Fosfatidiletanolaminas
/
Diterpenos
/
Dolicóis
/
Lipossomos
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article