Peripheral nerve injury by chymopapain injection.
J Neurosurg
; 61(1): 1-8, 1984 Jul.
Article
em En
| MEDLINE
| ID: mdl-6327941
ABSTRACT
Chymopapain injected into the intervertebral disc space (chemonucleolysis) has been used clinically in patients with disc disease with success. Neurosurgical complications secondary to the procedure have, however, been reported. In this study, the authors have investigated the possible neurotoxic effect of chymopapain on the peripheral nerve in rat and primate models. While the extrafascicular injection caused no nerve fiber damage, the intrafascicular injection caused dose-related nerve fiber damage in both species.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endopeptidases
/
Quimopapaína
/
Doenças do Sistema Nervoso Periférico
Limite:
Animals
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article