Cannabinoids in glaucoma II: the effect of different cannabinoids on intraocular pressure of the rabbit.
Curr Eye Res
; 3(6): 841-50, 1984 Jun.
Article
em En
| MEDLINE
| ID: mdl-6329602
ABSTRACT
Thirty-two different cannabinoids were tested for their ability to reduce intraocular pressure (IOP) in the rabbit. These included many of delta 9- and delta 8-THC derivatives and metabolites along with other natural and synthetic cannabinoids. In addition, some non-cannabinoid constituents of Cannabis were screened using the same model. All compounds were administered intravenously, while only a few were tested topically in mineral oil. Water soluble derivatives of delta 9- and delta 8-THC were prepared and tested topically in aqueous solution. The data revealed that certain derivatives of delta 9-and delta 8-THC were more active in lowering IOP than the parent cannabinoids. In addition, compounds other than delta 9- and delta 8-THC and their derivatives were shown to have activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canabinoides
/
Glaucoma
/
Pressão Intraocular
Limite:
Animals
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article