The protective effect of gamma-glutamyl L-dopa on the glycerol treated rat model of acute renal failure.
Clin Sci (Lond)
; 65(2): 159-64, 1983 Aug.
Article
em En
| MEDLINE
| ID: mdl-6407799
ABSTRACT
gamma-Glutamyl L-dopa, a renal pro-drug for dopamine, was administered to rats before and after injection of glycerol, and to a control group which received water in place of glycerol. A third group of rats was given glycerol but no gamma-glutamyl L-dopa. The plasma creatinine in rats given gamma-glutamyl L-dopa and glycerol was significantly lower than in rats receiving glycerol alone. The fall in urine creatinine excretion, and polyuria, after glycerol was reduced by gamma-glutamyl L-dopa and the natriuresis abolished. gamma-Glutamyl L-dopa given alone caused a 4000-fold increase in urine dopamine excretion, associated with a natriuresis. The administration of gamma-glutamyl L-dopa reduces the severity of renal failure produced by glycerol.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Di-Hidroxifenilalanina
/
Injúria Renal Aguda
Limite:
Animals
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article