Effect of T-2 toxin administration to rats on lipid metabolism in liver.
Toxicol Lett
; 22(1): 113-8, 1984 Jul.
Article
em En
| MEDLINE
| ID: mdl-6464031
ABSTRACT
The effect of oral dosing of rats with 1.5 mg T-2 toxin/kg body weight daily for 4 days on metabolism of liver lipids was studied. T-2 toxin significantly elevated total liver lipids, triglycerides, free cholesterol, total phospholipids and phosphatidyl choline, whereas the level of sphingomyelin + lysophosphatidyl ethanolamine was reduced. No change in the esterified cholesterol and phosphatidyl ethanolamine contents was observed. Incorporation of [1-14C]acetate into liver lipids, esterified cholesterol, triglycerides, free cholesterol and phosphatidyl ethanolamine was reduced in T-2 toxin-treated animals, implying reduced lipogenesis. Increased lipids in liver in T-2 toxin-treated rats are possibly due to an impaired secretion of lipids from the liver.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Toxina T-2
/
Radioisótopos de Carbono
/
Lipídeos
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article