Effect of indomethacin on collagen biosynthesis by rabbit articular chondrocytes in monolayer cultures.
Int J Tissue React
; 6(3): 233-41, 1984.
Article
em En
| MEDLINE
| ID: mdl-6480268
ABSTRACT
The influence of indomethacin on collagen biosynthesis in rabbit articular chondrocyte monolayer cultures was studied. Two applications within the space of three days of therapeutic doses (10(-5) or 10(-6)M), as well as repeated applications four days running of lower doses (10(-8) or 10(-10)M), increased the biosynthesis of both collagen and non-collagen proteins. Two applications of higher doses (10(-3) or 10(-4M) decreased DNA synthesis and inhibited both collagen and non-collagen protein biosynthesis. These results might well be considered in connection with the adverse reactions observed in some patients with long-term use of indomethacin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cartilagem Articular
/
Indometacina
/
Colágeno
Limite:
Animals
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article