Naloxone exacerbates hypoxic-ischemic brain injury in the neonatal rat.
Am J Obstet Gynecol
; 150(1): 52-6, 1984 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-6548084
ABSTRACT
Recent reports suggest that naloxone, an opiate antagonist, may adversely affect the asphyxiated fetus. We found that naloxone exacerbated hypoxic-ischemic brain injury in the 7-day-old rat subjected to unilateral common carotid artery ligation and hypoxia. Moreover, there was no amelioration of systemic acidosis or brain edema in naloxone-treated animals compared to animals treated with saline solution. High doses of naloxone may reduce the resistance of the fetus to hypoxic stress.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asfixia Neonatal
/
Encéfalo
/
Naloxona
Limite:
Animals
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Female
/
Humans
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Male
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Newborn
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article