Amiloride potentiation of differentiation of human promyelocytic cell line HL-60.
J Natl Cancer Inst
; 72(1): 13-7, 1984 Jan.
Article
em En
| MEDLINE
| ID: mdl-6582292
ABSTRACT
Cells of the human acute promyelocytic cell line HL-60 undergo differentiation when exposed to dimethyl sulfoxide (DMSO); in this report, amiloride, an inhibitor of passive intracellular Na+ flux, potentiated the DMSO-induced differentiation of HL-60 cells. This effect was seen at several concentrations of DMSO. Amiloride alone did not affect HL-60 differentiation. Various analogues of amiloride were tested for their ability to potentiate differentiation of HL-60 cells. The synergistic induction of myeloid differentiation by a membrane solvent (DMSO) and an Na+ transport inhibitor (amiloride) suggested membrane cation flux as being important in initiating differentiation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazinas
/
Leucemia Mieloide Aguda
/
Dimetil Sulfóxido
/
Amilorida
Limite:
Humans
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article