Heterogeneous pathways of Ca2+ metabolism in the triggering of the proliferative process in rat thymocytes.
Biochim Biophys Acta
; 762(1): 25-30, 1983 Feb 16.
Article
em En
| MEDLINE
| ID: mdl-6600936
ABSTRACT
Concanavalin A induces in rat thymocytes a calcium uptake at 1 h exposure and proliferative response after 24 h exposure. Phosphodiesterase activity parallels the proliferative response (thymidine uptake). Valinomycin, monensin and a small dose of ouabain also induce calcium uptake, but do not lead to thymidine uptake later. The latter treatments reduce, in some instances drastically, the concanavalin A response with respect to thymidine uptake. Trifluoperazine reduces the unstimulated thymidine uptake and the concanavalin A induced thymidine uptake. These results suggest that calcium has a decisive role in inducing proliferation but that some ways of increasing cellular Ca2+ concentration interfere in other steps with the DNA synthesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Linfócitos T
/
Cálcio
Limite:
Animals
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article