Spectrofluorometric determination of alkoxy-substituted benzylimidazolidinones in biological fluids.
J Pharm Sci
; 67(6): 752-6, 1978 Jun.
Article
em En
| MEDLINE
| ID: mdl-660447
ABSTRACT
Sensitive and specific spectrofluorometric assays were developed for the determination of d, 1-4-(3,4-dimethoxybenzyl)-2-imidazolidinone and d,1-4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone in blood and urine. Each compound is selectively extracted from buffered blood or urine and oxidized with alkaline permanganate to its respective fluorescent benzoic acid derivative, which is quantitated in acetic acid in ethanol (199). The method was applied to the determination of blood levels and urinary excretion in the dog following the administration of single intravenous and oral doses of each compound.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imidazóis
Limite:
Animals
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article