Relative subunit composition of the ferritin synthesized by selected human lymphomyeloid cell populations.
Exp Hematol
; 11(9): 866-72, 1983 Oct.
Article
em En
| MEDLINE
| ID: mdl-6605868
ABSTRACT
Biosynthesis of ferritin subunits by cell sets isolated from normal human peripheral blood, spleens of Hodgkin's disease patients, and tumor cell lines were investigated. Normal mature hematopoietic cells made a ferritin with more H (21K) than L (19K) subunits. The reverse was found for a promyelocytic tumor cell line and tumor cell lines derived from other tissues. Two dimensional electrophoresis indicated H has a lower pI than L. Therefore relative proportions of the two subunits contribute to the electrophoretically distinct forms of the isoferritins. In response to increasing concentrations of iron in vitro, a selected monocyte population synthesized more H than L; L biosynthesis however increased more than H. Some possible regulatory implications of these observations are discussed.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Linfócitos
/
Ferritinas
Limite:
Humans
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article