Quantitative study on the uterus-inhibiting activity of sodium naproxen in rat isolated uterus.
Methods Find Exp Clin Pharmacol
; 5(9): 625-9, 1983 Nov.
Article
em En
| MEDLINE
| ID: mdl-6668972
ABSTRACT
Action of Sodium Naproxen on spontaneous and field stimulated motility of isolated rat uterus was studied. Sodium Naproxen inhibited both spontaneous and field stimulated motility. The IC50 on spontaneous motility was lower than the IC50 on stimulated motility. The inhibition produced on the field stimulated uterus was more regular in relationship to concentration used of Sodium Naproxen. The IC50 of Sodium Naproxen in these experimental conditions was 8.22 X 10(-4) M (pD2 = 3.09 +/- 0.02) and the maximum inhibitory effect was 100%. These results show that prostaglandin synthesis plays a necessary role in uterine contraction, spontaneous or induced by field stimulus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Contração Uterina
/
Naproxeno
Limite:
Animals
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article