Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs. L1210 leukemia in mice.
J Med Chem
; 21(6): 563-74, 1978 Jun.
Article
em En
| MEDLINE
| ID: mdl-671453
ABSTRACT
Quantitative structure-activity relationships (QSAR) have been formulated for phenyl-, pyrazolyl-, and imidazolyltriazenes acting L1210 leukemia in mice. All three sets of congeners have the same ideal lipophilicity (log Po approximately 1). Electron releasing substituents increase potency; ortho substitution decreases activity. The synthesis of a number of new triazenes and some of their partition coefficients are reported.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triazenos
/
Leucemia L1210
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article