Effect of sodium fluoride on hepatic microsomal mixed-function oxidase system in newborn and adult male rats.

Administration i.p. of sodium fluoride at 2.5 or 5.0 mg/kg induced the mixed-function oxidase system in both newborn and adult rats; at 10.0 mg/kg there was induction in newborn rats and inhibition in adult rats, and at 20.0 mg/kg, there was inhibition in both newborn and adults.