Asbestos-related fibrin formation in human plasma.
Thromb Res
; 34(4): 311-9, 1984 May 15.
Article
em En
| MEDLINE
| ID: mdl-6740564
ABSTRACT
This study was designed to test the hypothesis that asbestos is responsible for the activation of clotting, for the reduction in activity of clotting factors and for the formation of fibrin when human plasma is exposed to asbestos chrysotile fibers in vitro. The recalcification time was accelerated in the early phase and was found to be greatly prolonged at 24 hours. The activated partial thromboplastin time showed marked changes at 24 hours only. One group of clotting factors, consisting of factors V, IX and X, showed the greatest decrease in their plasmatic activity. The factors least changed were factors XII and VIII; the other clotting factors were found in between these groups. Histologic examination demonstrated fibrin fibers in close proximity to the asbestos. Thus, chrysotile asbestos fibers activate clotting with the subsequent decrease in activity of some coagulation factors resulting in the formation of fibrin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amianto
/
Coagulação Sanguínea
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Humans
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article