A new series of Tc-99m-labeled hepatobiliary tracers: N'-acyl- and N'-sulfonyl ethylenediamine-N,N-diacetic acids.
J Nucl Med
; 22(7): 619-22, 1981 Jul.
Article
em En
| MEDLINE
| ID: mdl-6788907
ABSTRACT
Various Tc-99m-labeled N'-substituted derivatives of ethylenediamine-N,N-diacetic acid (EDDA) are evaluated as hepatobiliary imaging agents. N-substituted aromatic acyl and aromatic sulfonyl derivatives of EDDA, labeled with Tc-99m, were administered to rabbits and golden hamsters, and the distribution indicated clearance by the hepatobiliary system. N'-aromatic sulfonyl EDDAs were labeled with Tc-99m by the SnCl2 method with more than 99% yield. Clearance of Tc-99m-p-toluenesulfonyl EDDA from the blood and the liver was as rapid as that of TC-99m N-(2,6-diethylphenylcarbamoylmethyl)iminodiacetic acid (Tc-99m benzenesulfonyl EDDA lowered urinary excretion. It is concluded that the sulfonyl EDDAs provide a fruitful source for Tc-99m-labeled hepatobiliary radiopharmaceuticals.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Biliar
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Compostos de Organotecnécio
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Tecnécio
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Ácido Edético
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Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article