[Use of silatranes in combination with Vishnevskii'n ointment in wound treatment]. / Ispol'zovanie silatranov v sochetanii s maz'iu Vishnevskogo dlia lecheniia ran.
Biull Eksp Biol Med
; 95(3): 100-3, 1983 Mar.
Article
em Ru
| MEDLINE
| ID: mdl-6830973
ABSTRACT
Experiments on rats were performed to study the effect of I-/chlormethyl/silatrane and I-/ethoxy/silatrane as well as that of triethanolamine and /chlormethyl/triethoxysilane on the biochemical characteristics of granular-fibrous tissue. The drugs were applied to the wound in the form of liniments. Silatranes stimulated cell proliferation and raised biosynthetic activity of the cells. They also favoured collagen and non-collagenous protein accumulation and reduced the inflammatory manifestations. The silicon-containing fragment of the silatrane molecule, /chlormethyl/triethoxysilane, produced an analogous but less pronounced action. Triethanolamine containing no silicon appeared to be far less active. These data indicate that the presence of silicon in the silatrane grouping is of great importance for its effective biological function.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Silício
/
Cicatrização
/
Ferimentos e Lesões
/
Compostos Bicíclicos com Pontes
/
Hidrocarbonetos Aromáticos com Pontes
/
Compostos de Organossilício
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Compostos Bicíclicos Heterocíclicos com Pontes
/
Tecido de Granulação
Limite:
Animals
Idioma:
Ru
Ano de publicação:
1983
Tipo de documento:
Article