Studies on v-triazoles. 9. Antiallergic 4,9-dihydro-4,9-dioxo-1H-naphtho[2,3-d]-v-triazoles.
J Med Chem
; 26(5): 714-9, 1983 May.
Article
em En
| MEDLINE
| ID: mdl-6842510
ABSTRACT
A short series of the title compounds was prepared and evaluated for antiallergic activity in the rat passive cutaneous anaphylaxis screen. All but the two N-methylated derivatives were active in this screen by the intravenous route, the most potent being the symmetrical dimethyl compound, 4,9-dihydro-6,7-dimethyl-4,9-dioxo-1H-naphtho[2,3-d]-v-triazole, and its 5-nitro derivative. The latter two compounds were noticeably more potent than disodium cromoglycate, and one of these, the unnitrated material, was selected for further evaluation as a potential antiasthmatic drug.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
Hipersensibilidade
Limite:
Animals
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article