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A new series of steroidal antidysrhythmic agents.
J Steroid Biochem ; 19(1C): 759-65, 1983 Jul.
Article em En | MEDLINE | ID: mdl-6887895
With the aim of finding an antidysrhythmic agent suitable for intravenous or oral administration we have examined a range of steroids carrying basic substituents. The primary screen involved control of cardiac dysrhythmias induced by intravenous infusion of aconitine into pentobarbitone-anaesthetised artificially-respired rats. The best activity was found among a series of 11 alpha-alkylamino steroids and structure-activity studies included modification of the alkylamino group and variation of substituents in ring A and at the 17-position. Good oral and intravenous activity was found among 17 beta-methoxycarbonyl-5 alpha-androstanes and methyl 2 beta-ethoxy-3 alpha-hydroxy-11 alpha-(3-methylbutylamino)-5 alpha-androstane-17 beta-carboxylate hydrochloride (CCI 22277) was selected for more detailed pharmacological study.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Esteroides / Antiarrítmicos Limite: Animals Idioma: En Ano de publicação: 1983 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Esteroides / Antiarrítmicos Limite: Animals Idioma: En Ano de publicação: 1983 Tipo de documento: Article