Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on embryonic chick bone in organ culture.
J Exp Zool
; 224(1): 97-101, 1982 Nov 20.
Article
em En
| MEDLINE
| ID: mdl-6897420
ABSTRACT
The ability of embryonic chick bone to respond to 25 hydroxyvitamin D3 and 1,25 dihydroxyvitamin D3 was assessed in organ culture. These metabolites were added to prelabeled chick embryo long-bone explants, and the amount of calcium-45 released into the medium after 24 or 48 h of hormone exposure was measured. For each time period a significant release of calcium-45 from hormone-treated bones was observed. The response to 25 hydroxyvitamin D3 and 1,25 dihydroxyvitamin D3 was always greater at 48 h and a clear dose-dependency was established at this time as well. 1,25 dihydroxyvitamin D3 was the more potent resorbing agent at all concentrations tested. The results from this study suggest that vitamin D metabolites may be involved in bone regulation in the chick embryo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osso e Ossos
/
Calcifediol
/
Calcitriol
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article