Destruction of human solid tumors by alkyl lysophospholipids.
J Natl Cancer Inst
; 64(6): 1301-6, 1980 Jun.
Article
em En
| MEDLINE
| ID: mdl-6929370
ABSTRACT
Alkyl lysophospholipids (ALP) are synthetic analogs of the naturally occurring 2-lysophosphatidylcholine. The effect of ALP on the proliferation of 22 different gynecologic malignant tumors in humans was studied in vitro. ALP caused progressive death of tumor cells over 24-96 hours. In addition, tumor specimens from the tested human tumors were xenotransplanted into NMRI nude mice. ALP induced a highly significant retardation of the in vivo growing human tumors. Neither oral nor iv administration of these compounds caused any recognizable side effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Lisofosfatidilcolinas
/
Neoplasias dos Genitais Femininos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article