Lymphocytotoxic anti-LewisbH antibody.
Transplantation
; 31(6): 449-51, 1981 Jun.
Article
em En
| MEDLINE
| ID: mdl-6973224
ABSTRACT
We wish to report strong lymphocyte crossmatch incompatibility attributable to anti-Lea antibody. The prospective renal transplant recipient was Le(a-b-) and her serum contained potent anti-Lea and anti-LebH antibodies. Despite the fact that were able to demonstrate greater B lymphocyte than T lymphocyte Lewis(a+) antigenicity, this serum was capable of causing greater than 80% cytotoxicity of Le(a+) and Le(b+)O or A2 whole lymphocyte populations. Antibody activity was completely inhibited by Lewis substance. This inhibition was specific and did not interfere with HLA antibody activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos do Grupo Sanguíneo de Lewis
/
Soro Antilinfocitário
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article