Functional properties of human thymoma lymphocytes: role of subcellular factors in blastic activation.
J Natl Cancer Inst
; 69(4): 827-31, 1982 Oct.
Article
em En
| MEDLINE
| ID: mdl-6981722
ABSTRACT
The proliferative responses to phytohemagglutinin and the role of subcellular factors in the modulation of blastogenesis of thymoma lymphocytes from 5 thymoma patients were investigated. The addition of exogenous interleukin 1, a macrophage product, strongly augmented the blastic transformation of cultured thymocytes from both normal and neoplastic glands by influencing the production of interleukin 2 (IL-2) by a well-defined T-cell subset. The magnitudes of the blastic responses were ultimately modulated by the amount of IL-2 released in culture. The higher proliferative responses exhibited by thymocytes from thymoma were effectively sustained by a higher production of IL-2 in culture. In addition to having distinctive surface membrane receptors in common with normal thymocytes, thymoma lymphocytes were also under the influence of the same subcellular factors involved in T-cell blastic activation as thymocytes. These observations imply the presence of functionally distinct subpopulations in the thymoma lymphocyte component and add arguments in favor of their nonneoplastic nature.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timoma
/
Neoplasias da Glândula Tireoide
/
Ativação Linfocitária
/
Linfócitos
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article