Selective effects of morphine on the nociceptive responses of thalamic neurones in the rat.
Br J Pharmacol
; 64(1): 137-43, 1978 Sep.
Article
em En
| MEDLINE
| ID: mdl-698478
ABSTRACT
1. The effects of intravenous morphine on the firing of single sensory neurones in the thalamus of the anaesthetized rat are described. 2. Low doses (0.38 to 2.00 mg/kg) of morphine depressed the excitation of nucleus lateralis neurones produced by natural noxious stimuli but were without effect on spontaneous activity. The excitation of some of these neurones by iontophoretically applied acetylcholine or glutamate was also depressed by morphine. These effects were reversed by intravenous (0.25 to 1.17 mg/kg) but not iontophoretically applied (50 to 200 nA) naloxone. 3. Similar or higher doses of morphine (0.58 to 5.07 mg/kg) did not prevent the excitation of ventrobasal thalamic neurones by non-noxious stimuli. 4. The possibility of a direct action of intravenous morphine in the thalamus is discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Tálamo
/
Morfina
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article