Synthesis and pharmacological properties of some 2-pyrrolidinone Mannich bases.
Pol J Pharmacol Pharm
; 34(5-6): 373-82, 1982.
Article
em En
| MEDLINE
| ID: mdl-6985304
ABSTRACT
N-aminoalkyl derivatives of 2-pyrrolidinone (1-5) and methylene-bis-amino derivatives (7-9) as intermediary products formed during aminoalkylation were described. Compounds 2 and 3, in doses over 30 and 20 mg/kg resp., displayed analgesic properties; compound 3 exerted also a weak anti-inflammatory action (37 mg/kg po) in the carrageenin test.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinonas
/
Aminas
/
Bases de Mannich
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article