Further studies on the structure-activity relationships of bradykinin-potentiating peptides.
Eur J Pharmacol
; 79(1-2): 155-8, 1982 Apr 08.
Article
em En
| MEDLINE
| ID: mdl-7084307
ABSTRACT
Several pentapeptides were synthesized and tested for bradykinin-potentiating activity. From these and previous data it appeared that an (L)-aromatic amino acid residue (preferably Trp) in position 3 is essential for high activity. Position 3 represents a stereospecific pillar function, whereas the other positions and the lipophilicity/hydrophilicity balance are important for additional activity. So far, BPP5a seems to have the optimal structure for a bradykinin-potentiating pentapeptide.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Bradicinina
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article