The pharmacological assessment of a new, potent oxotremorine analogue in mice and rats.
Eur J Pharmacol
; 80(2-3): 209-15, 1982 May 21.
Article
em En
| MEDLINE
| ID: mdl-7106176
ABSTRACT
Some of the central and peripheral effects of oxotremorine (OT) and its azetidine analogue, N-[4-azetidinyl)-2-butynyl]-2-pyrrolidone (BM 120), were compared in mice and rats. BM 120 was found to be about twice as potent as OT and to have a somewhat longer duration of action. All its effects were antagonized by pretreatment with atropine sulphate. BM 120 acted as powerful muscarinic agonist on the isolated guinea pig ileum.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxotremorina
/
Parassimpatomiméticos
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article