Effect of a concomitant treatment with ethynylestradiol and ascorbic acid on bile secretion in female hamsters.
Methods Find Exp Clin Pharmacol
; 4(5): 313-6, 1982.
Article
em En
| MEDLINE
| ID: mdl-7121137
ABSTRACT
The administration of large doses (5 mg/kg b.wt./day) of ethynylestradiol to adult female hamsters did not induce cholestasis or modifications of bile lipid composition. These findings are in contrast with the data of other authors who in different experimental conditions described the sensitivity of hamsters to the estrogen-induced hepatobiliary toxicity. Ascorbic acid alone or added to ethynylestradiol did not impair bile secretion. However, it significantly increased the plasma levels of radioactivity tested 24 hours after the oral administration of a tracer dose of radiolabelled ethynylestradiol. These results confirm previous data showing in humans the capability of ascorbic acid to favour the rise of plasma concentrations of ethynylestradiol.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Bile
/
Etinilestradiol
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article