The study of X-rays and TCDD effects on satellite associations may suggest a simple model for application in environmental mutagenesis.
Hum Genet
; 61(1): 42-7, 1982.
Article
em En
| MEDLINE
| ID: mdl-7129425
ABSTRACT
Satellite associations were used as parameters to test nucleolar organizer activity. Assuming that toxic and/or mutagenic agents may affect the ribosomal genes, satellite associations in human lymphocytes were analysed following exposure to X-rays and compared with the satellite association pattern of subjects exposed to TCDD. A significant decrease in the satellite association frequency in D group chromosomes was found both in irradiated lymphocytes and in subjects exposed to Dioxin. The findings seem to be in accordance with the hypothesis based on random damage of functional nucleolar organizing regions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Satélite
/
Dioxinas
/
Dibenzodioxinas Policloradas
/
Região Organizadora do Nucléolo
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article