The effect of food on the absorption of phenylbutazone from a commercial 100 mg enteric-coated tablet.
J Clin Hosp Pharm
; 7(3): 175-9, 1982 Sep.
Article
em En
| MEDLINE
| ID: mdl-7174832
ABSTRACT
It is recommended that many drugs be taken with or after meals. Recently, however, food intake has been shown to alter significantly the rate and/or extent of absorption of many drugs. Such alterations may induce important changes in the clinical activity of these drugs. Enteric-coated phenylbutazone is recommended to be taken with food to minimize possible gastro-intestinal side-effects. The results of this study demonstrate that while food delays the onset of absorption from this formulation by 4-5 h, it has no significant effect on the peak concentration or area under the curve. Thus, some effect on fluctuation in plasma levels at steady-state would be expected, but the mean concentration over the recommended dosage interval would remain the same. Treatment efficacy should therefore be unaffected by food but the tolerability may be improved.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilbutazona
/
Alimentos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article