Polymers for sustained macromolecule release: procedures to fabricate reproducible delivery systems and control release kinetics.
J Pharm Sci
; 69(3): 265-70, 1980 May.
Article
em En
| MEDLINE
| ID: mdl-7189778
ABSTRACT
Matrixes composed of ethylene-vinyl acetate copolymer are useful vehicles for the sustained release of macromolecules such as proteins. A new procedure for fabricating these polymeric delivery systems involved mixing the dry, powdered macromolecule with a polymer solution and casting the mixture at -80 degrees. The resulting matrix was dried in two 48-hr stages, first at -20 degress and then at 20 degrees. These polymer systems had uniform drug distribution, and their release kinetics were reproducible. Fabrication parameters such as drug particle size, drug loading, and matrix coating all significantly affected release kinetics.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Preparações de Ação Retardada
/
Substâncias Macromoleculares
Limite:
Animals
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article