Astatine-211--tellurium radiocolloid cures experimental malignant ascites.
Science
; 212(4492): 340-1, 1981 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-7209534
ABSTRACT
An investigation of the efficacy of astatine-211--tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this alpha-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with alpha-emission. These results have important implications for the development and use of alpha-emitters as radiocolloid therapy for the treatment of human tumors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascite
/
Radioisótopos
/
Telúrio
/
Astato
/
Compostos de Cromo
/
Neoplasias Experimentais
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article