New synthetic routes to tilorone dihydrochloride and some of its analogues.
J Med Chem
; 21(10): 1084-6, 1978 Oct.
Article
em En
| MEDLINE
| ID: mdl-722716
ABSTRACT
New synthetic routes to the orally active, interferon-inducing antiviral agent tilorone dihydrochloride, 2,7-bis-[(diethylamino)ethoxy]fluoren-9-one dihydrochloride (1a), were developed. The routes involved the preparation and solvolysis of tetrazonium fluoroborate salts of 2,7-diaminofluoren-9-one. Nonplanar (1b), 9-sulfone (1c), and fluorene (1d) analogues of tilorone dihydrochloride were also prepared. Compounds 1b and 1c were evaluated for interferon induction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tilorona
/
Fluorenos
Limite:
Animals
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article