Inhibition of rat platelet 5-hydroxytryptamine uptake by chlordimeform.
Toxicol Lett
; 9(1): 1-4, 1981 Sep.
Article
em En
| MEDLINE
| ID: mdl-7302966
ABSTRACT
Chlordimeform, a formamidine insecticide and acaricide, and two of its toxic N-demethyl metabolites inhibited rat blood platelet 5-hydroxytryptamine (5-HT) uptake. A direct relationship existed between formamidine uptake inhibitory potency and N-demethylation. Didemethylchlordimeform, the most potent formamidine inhibitor of 5-HT uptake examined, had a pI50 of 4.2. However, it was appreciably less active than the classical inhibitor imipramine, which yielded 86.4% inhibition of 5-HT uptake at a concentration of 1.10(-5) M.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Serotonina
/
Clorfenamidina
/
Amidinas
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article