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Myasthenia due to carnitine treatment.
J Neurol Sci ; 46(3): 365-71, 1980 Jun.
Article em En | MEDLINE | ID: mdl-7381520
Severe weakness of lower cranial and girdle muscles has been found in 4 subjects among 20 dialysis patients treated with carnitine in order to correct their high plasma triglyceride level. Neurophysiological investigation showed an impairment of neuromuscular transmission with short-term reduction of evoked muscle responses to repetitive stimulation and the presence of "post-activation exhaustion phenomenon" 3 min after the train. Both the weakness and the neurophysiological findings were less pronounced after edrophonium. These findings suggest a hemicholinium activity of carnitine at synaptic level.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina / Doenças Musculares Limite: Adult / Humans / Middle aged Idioma: En Ano de publicação: 1980 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina / Doenças Musculares Limite: Adult / Humans / Middle aged Idioma: En Ano de publicação: 1980 Tipo de documento: Article